
Premier Analytics Consulting at the Midwest SAS® Users Group (MWSUG) 2026 Conference
Professional training, papers, and presentations delivered at the MWSUG 2026 Conference in Madison, Wisconsin.
Premier Analytics Consulting, LLC brings our applied experience in data science, enterprise AI, clinical analytics, and open-source integration to MWSUG 2026 in Madison, Wisconsin. Across technical papers and panel discussions, our team will cover reproducible workflows with Git, GitHub, DVC, and MLflow; practical AI roadmaps; secure AI agents for clinical and regulatory work; and Python integration with SAS® Viya® through PROC PYTHON.
Ryan Paul Lafler will also lead a half-day workshop on statistical analysis for clinical and regulatory reporting using R, Python, and SAS® 9.4. The course follows the analytical lifecycle from study protocol and SAP through power analysis, hypothesis testing, TLF development, and CSR-ready reporting, with hands-on methods attendees can apply directly in regulated work.
Hands-On Training Workshop
Training developed and delivered by the Premier Analytics Consulting team.
Mastering Statistical Analysis in the Age of AI with R, Python, and SAS® for Clinical and Regulatory Reporting
Ryan Paul Lafler
Date: November 15, 2026
Time: 8:00 AM - 12:00 PM CT
Location: Madison, Wisconsin
Training Workshop Description
This hands-on workshop introduces clinical and regulatory statistical analysis using Python, R, and SAS® 9.4. It begins with key ICH guidelines and FDA requirements, then follows the analytical lifecycle from the study protocol and Statistical Analysis Plan (SAP) through analysis, TLF generation, and presentation of results for the Clinical Study Report (CSR). Emphasis is placed on statistical planning, analysis, and reporting. Designed for clinical and statistical programmers, data scientists, analysts, researchers, students, and professionals working in clinical, pharmaceutical, regulatory, and applied research settings, this workshop connects exploratory data analysis, power analysis, hypothesis testing, and regulatory reporting in one training session. Attendees will compare implementations across Python, R, and SAS 9.4, including syntax, output, diagnostics, and interpretation. Through discussions and hands-on exercises, attendees will learn how to: ➤ Identify key ICH guidelines, FDA requirements, and expectations for reproducible and defensible analysis ➤ Follow the clinical analytical lifecycle from study protocol and SAP through analysis, TLF generation, and the CSR ➤ Recognize the role of common AI programming copilots, human oversight, and enterprise requirements ➤ Perform exploratory data analysis (EDA), summarization, and visualization across Python, R, and SAS 9.4 ➤ Explain Type I and Type II errors, statistical power, effect sizes, and sample size considerations ➤ Select parametric and nonparametric methods based on the research question, data structure, and assumptions ➤ Compare two populations using Welch’s two-sample t-test and the Mann-Whitney U test ➤ Compare multiple populations using ANOVA and the Kruskal-Wallis test and assess diagnostics ➤ Generate tables, listings, and figures (TLFs) from results across programming languages ➤ Prepare clear statistical results and interpretations for inclusion in the CSR By the end of this workshop, attendees will be able to understand the clinical analytical lifecycle and the role of AI in regulated environments. They will be able to assess statistical power; select and implement appropriate methods; evaluate model assumptions; interpret statistical and clinical significance; and translate validated analyses into TLFs and CSR-ready reporting in Python, R, and SAS. All registered attendees will receive the non-redistributable PDF slides, fully documented Python and R notebooks, SAS programs, and workshop datasets to reproduce the analyses and continue enhancing their skills.
Published Technical Papers
Technical papers authored and published by the Premier Analytics Consulting team.
Building Better Data Science Workflows: Best Practices with Git, GitHub, Data Version Control (DVC), and MLflow for Open-Source Collaboration
Ryan Paul Lafler
Abstract
This paper presents a practical framework for building reliable, reproducible, and collaborative data science workflows using Git, GitHub, Data Version Control (DVC), and MLflow. It begins by introducing Git as the foundation for tracking code changes and GitHub as a collaboration layer for shared repositories, branching strategies, pull requests, and team-based development. DVC is then presented as an extension to version control that enables datasets, intermediate outputs, and analytical artifacts to be tracked, compared, and restored alongside code without storing large files directly in Git repositories. The paper demonstrates strategies and techniques for meaningful commit practices, managing work-in-progress (WIP) safely, reducing merge conflicts, and maintaining structured project histories across collaborative environments. Building on this foundation, MLflow is introduced as a lightweight experiment tracking and model management layer for machine learning workflows in Python, allowing teams to record training runs, fine-tuning parameters, evaluation metrics, model artifacts, and performance comparisons during iterative development. Together, Git, GitHub, DVC, and MLflow provide an integrated open-source ecosystem for managing code repositories, versioning data, and tracking model experiments across collaborative data science, machine learning, and analytics projects.
Keywords: Git; GitHub; Data Version Control (DVC); MLflow; Reproducible Research; Data Science Workflows; Machine Learning Workflows; MLOps; Data Engineering; Experiment Tracking; Clinical Trials; Reproducible Analytics
Section: Open Source Development and Tools
Charting Your Organization's AI Roadmap: A Practical Approach from Machine Learning Foundations to Generative and Agentic AI
Ryan Paul Lafler
Abstract
Artificial Intelligence (AI) continues to reshape business, technology, science, and research by enabling systems to learn from data, automate workflows, and support more adaptive decision-making. This paper presents a practical roadmap for understanding AI through the progression from machine learning (ML) foundations to modern generative and agentic AI systems. It introduces AI as a broad field and machine learning as a data-driven approach to AI, then examines supervised learning for predictive analytics on labeled data, unsupervised learning for pattern discovery in unlabeled data, and generative learning for representation learning, synthesis, reasoning, and content generation. The paper introduces key algorithms, architectures, use cases, model hyperparameters, and practical considerations such as overfitting, underfitting, and model evaluation to support applied implementation across industry settings. It concludes by connecting deep learning with modern generative model architectures, including encoder models, decoder-only large language models, and encoder-decoder models, to the emerging shift toward agentic AI systems that combine models with retrieval, tools, APIs, and workflow orchestration to support practical industry use cases in 2026, 2027, and beyond.
Keywords: Enterprise AI; Supervised ML; Unsupervised ML; Generative AI; Agentic AI; Open-Source AI; Deep Learning; Neural Networks; Transformer Architectures; AI Integration; Predictive Analytics; Data Mining
Section: AI, Statistics and Analytic Methods
Building the 2027 Clinical AI Stack: Secure AI Agents for Clinical Development and Regulatory Submissions
Ryan Paul Lafler
Abstract
Clinical AI is moving beyond standalone copilots and experimental chatbots, creating a need for secure, traceable systems that can support clinical development and regulatory submission workflows through 2027 and beyond. This paper presents a practical roadmap for applying AI to focused use cases, including protocol and statistical analysis plan review, SDTM and ADaM mapping support, TLF development, CSR contextualization, and submission-readiness checks. It connects these use cases to core components of the clinical AI stack, including AI agents, retrieval-augmented generation, vector search, tool integration, and proprietary or locally deployed language models. Implementation patterns are presented primarily in Python, with connections to R and SAS® Viya® workflows. This paper presents a staged roadmap for integrating AI workflows that assist clinical and regulatory teams while maintaining QA/QC and human-in-the-loop review.
Tags: Clinical AI; AI Agents; Clinical Development; Regulatory Submissions; SDTM; ADaM; Retrieval-Augmented Generation; Locally Deployed Language Models; Human-in-the-Loop Review
Section: AI, Statistics and Analytic Methods
Enhancing Your SAS® Viya® Workflows with Python: Integrating Python's Open-Source Libraries with SAS using PROC PYTHON
Ryan Paul Lafler; Miguel Angel Bravo
Abstract
Developers, data scientists, and analysts are increasingly leveraging open-source tools and libraries to integrate with and enhance their existing data engineering and analytical workflows. One of these integrations, built into SAS® Viya®, is its pre-configured Python runtime integration, PROC PYTHON, that gives SAS programmers access to Python's open-source data science libraries for processing, visualizing, and analyzing data alongside SAS procedures. This presentation demonstrates how to access and use Python libraries in Viya runtimes; understand data-handling in Python and SAS; build Python scripts with reusable methods that import, process, and analyze data; and execute those Python methods to export Pandas DataFrames as SAS datasets.
Keywords: SAS® Viya®; PROC PYTHON; SAS-Python Integration; Open-Source Integration; Hybrid Analytics Workflows; Data Engineering; Pandas Library; SAS Dataset; Software Interoperability
Section: Open Source Development and Tools
Panel Discussion
MWSUG AI Panel - How Are You Using AI?
Arpita Deb; Joe Madden; Ryan Paul Lafler
Date: November 16, 2026
Time: 12:30 PM - 1:30 PM CT
Panel Description
Ryan Paul Lafler of Premier Analytics Consulting, LLC will join Arpita Deb and Joe Madden for a practical discussion on how SAS® programmers are using AI in their work. The panel will examine which tools are proving useful, where AI can accelerate programming and analytics, and how these capabilities are being applied across clinical research, product development, and enterprise data workflows.
MWSUG 2026 Conference Highlights
See the Premier Analytics Consulting team in action.
![]() Mastering Statistical Analysis in the Age of AI with R, Python, and SAS® for Clinical and RegulatoryTraining workshop on clinical and statistical analysis in the age of AI using Python, R, and SAS®. Taught by Ryan Paul Lafler at the MWSUG 2026 Conference on November 15, 2026. |
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Expert services and solutions in AI, data engineering, full-stack systems, advanced statistical analysis, enterprise GIS, and open-source modernization.
Premier Analytics Consulting helps organizations deliver secure, modern, and data-driven solutions across AI, data engineering, full-stack architectures, advanced statistical analysis and reporting, enterprise GIS, environmental informatics, and open-source modernization. We welcome opportunities for contracting, subcontracting, technical partnerships, advisory support, training, and project-based assignments, and support clients with specialized implementation, analytical workflows, solution architecture, and modern data system development across business, enterprise, research, and public-sector environments.

